Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …

Compositional diversity is a fundamental property in cell populations. Single‐cell analysis
promises new insight into this cellular heterogeneity on the genomic, transcriptomic …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

Motivation The analysis of RNA-Seq data from individual differentiating cells enables us to
reconstruct the differentiation process and the degree of differentiation (in pseudo-time) of …

A substantial amount of phenotypic diversity results from changes in gene expression levels
and patterns. Understanding how the transcriptome evolves is therefore a key priority in …

G protein-coupled receptors (GPCRs) are targets for∼ 35% of approved drugs but only∼
15% of the∼ 800 human GPCRs are currently such targets. GPCRomics, the use of …

Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …

Background Skin transcriptome studies in atopic dermatitis (AD) showed broad
dysregulation as well as “improvement” under therapy. These observations were mainly …

Detecting pancreatic duct adenocarcinoma (PDAC) in its early stages and predicting late‐
stage patient prognosis undergoing chemotherapy is challenging. This work shows that the …

Data-independent acquisition (DIA) has revolutionized the field of mass spectrometry (MS)-
based proteomics over the past few years. DIA stands out for its ability to systematically …