Dihydrodipicolinate synthase (DHDPS) is critical to the production of lysine through the
diaminopimelate (DAP) pathway. Elucidation of the function, regulation and structure of this …

Here, we review recent studies aimed at defining the importance of quaternary structure to a
model oligomeric enzyme, dihydrodipicolinate synthase. This will illustrate the …

Analytical ultracentrifugation is a widely used method for characterizing the solution
behavior of macromolecules. However, the two commonly used detectors, absorbance and …

Sedimentation velocity (SV) analytical ultracentrifugation (AUC) is a classic technique for the
real-time observation of free macromolecular migration in solution driven by centrifugal …

Dihydrodipicolinate synthase (DHDPS) catalyzes the first committed step in the lysine
biosynthesis pathway of bacteria. The pathway can be regulated by feedback inhibition of …

Diaminopimelate (DAP) epimerase is involved in the biosynthesis of meso-DAP and lysine,
which are important precursors for the synthesis of peptidoglycan, housekee** proteins …

Diaminopimelate decarboxylase (DAPDC) catalyzes the final step in the diaminopimelate
biosynthesis pathway of bacteria. The product of the reaction is the essential amino acid l …

In plants, the lysine biosynthetic pathway is an attractive target for both the development of
herbicides and increasing the nutritional value of crops given that lysine is a limiting amino …

Bacillus anthracis is a Gram-positive spore-forming bacterium that causes anthrax. With the
increased threat of anthrax in biowarfare, there is an urgent need to characterize new …

Lysine biosynthesis in bacteria and plants commences with a condensation reaction
catalysed by dihydrodipicolinate synthase (DHDPS) followed by a reduction reaction …