Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …

The C-terminal domain (CTD) of the RNA polymerase II largest subunit consists of multiple
heptad repeats (consensus Tyr1–Ser2–Pro3–Thr4–Ser5–Pro6–Ser7), varying in number …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

Regulation of gene expression is integral to the development and survival of all organisms.
Transcription begins with the assembly of a pre-initiation complex at the gene promoter …

Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor in clinical
trials as a cancer therapy that has been recently shown to block human immunodeficiency …

The elongation phase of transcription by RNA polymerase II is one of the many steps during
the generation of mature mRNAs that is subject to regulation. Shortly after initiation, RNA …

The elongation of transcription is a highly regulated process that requires negative and
positive effectors. By binding the double-stranded stem in the transactivation response …

To stimulate transcriptional elongation of HIV-1 genes, the transactivator Tat recruits the
positive transcription elongation factor b (P-TEFb) to the initiating RNA polymerase II …

Replication-competent latent HIV-1 proviruses that persist in the genomes of a very small
subset of resting memory T cells in infected individuals under life-long antiretroviral therapy …