Animal functional magnetic resonance imaging: trends and path toward standardization
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive
window into brain activity. A collection of associated methods aims to replicate observations …
window into brain activity. A collection of associated methods aims to replicate observations …
Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists
Drugs acting at metabotropic glutamate receptors (mGluRs) are among the most promising
agents under development for the treatment of psychiatric disorders. The research in this …
agents under development for the treatment of psychiatric disorders. The research in this …
[HTML][HTML] Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
The hippocampus in schizophrenia is characterized by both hypermetabolism and reduced
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
size. It remains unknown whether these abnormalities are mechanistically linked. Here we …
(2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions
Currently approved antidepressant drugs often take months to take full effect, and∼ 30% of
depressed patients remain treatment resistant. In contrast, ketamine, when administered as …
depressed patients remain treatment resistant. In contrast, ketamine, when administered as …
Utility of imaging-based biomarkers for glutamate-targeted drug development in psychotic disorders: a randomized clinical trial
Importance Despite strong theoretical rationale and preclinical evidence, several glutamate-
targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions …
targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions …
Pharmacologic magnetic resonance imaging (phMRI): imaging drug action in the brain
BG Jenkins - Neuroimage, 2012 - Elsevier
The technique of functional magnetic resonance (fMRI), using various cognitive, motor and
sensory stimuli has led to a revolution in the ability to map brain function. Drugs can also be …
sensory stimuli has led to a revolution in the ability to map brain function. Drugs can also be …
Test–retest reliability of the BOLD pharmacological MRI response to ketamine in healthy volunteers
The pharmacological MRI (phMRI) technique is being increasingly used in both pre-clinical
and clinical models to investigate pharmacological effects on task-free brain function …
and clinical models to investigate pharmacological effects on task-free brain function …
The M1/M4 preferring muscarinic agonist xanomeline modulates functional connectivity and NMDAR antagonist-induced changes in the mouse brain
Cholinergic drugs acting at M1/M4 muscarinic receptors hold promise for the treatment of
symptoms associated with brain disorders characterized by cognitive impairment, mood …
symptoms associated with brain disorders characterized by cognitive impairment, mood …
Astrocytic regulation of glutamate transmission in schizophrenia
YY Mei, DC Wu, N Zhou - Frontiers in psychiatry, 2018 - frontiersin.org
According to the glutamate hypothesis of schizophrenia, the abnormality of glutamate
transmission induced by hypofunction of NMDA receptors (NMDARs) is causally associated …
transmission induced by hypofunction of NMDA receptors (NMDARs) is causally associated …
Functional magnetic resonance imaging reveals different neural substrates for the effects of orexin-1 and orexin-2 receptor antagonists
A Gozzi, G Turrini, L Piccoli, M Massagrande… - PloS one, 2011 - journals.plos.org
Orexins are neuro-modulatory peptides involved in the control of diverse physiological
functions through interaction with two receptors, orexin-1 (OX1R) and orexin-2 (OX2R) …
functions through interaction with two receptors, orexin-1 (OX1R) and orexin-2 (OX2R) …