It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Stim1 and Orai1 are ubiquitous proteins that have long been known to mediate Ca2+
release-activated Ca2+ (CRAC) current (ICRAC) and store-operated Ca2+ entry (SOCE) …

Processes that are important in cancer progression, such as sustained cell growth, invasion
to other organs, and resistance to cell death inducers, have a clear overlap with pathways …

Calcium (Ca2+) regulates a plethora of cellular functions including hallmarks of cancer
development such as cell cycle progression and cellular migration. Receptor-regulated …

Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon
binding to target proteins transduces signals encoded by global or subcellular-specific …

Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events
including cell migration. Directional cell migration requires the polarization of both signaling …

Aims Doxorubicin (DOX)‐induced heart failure has a poor prognosis, and effective
treatments have not been established. Because DOX shows cumulative cardiotoxicity, we …

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine
kinases best known for its critical role in learning and memory. Recent studies suggested …