Immunoglobulin E (IgE)‐mediated allergy is the most common hypersensitivity disease
affecting more than 30% of the population. Exposure to even minute quantities of allergens …

Food allergy is a major public health issue with growing prevalence in the urbanized world
and significant impact on the lives of allergic patients and their families. Research into the …

Background Oral immunotherapy is effective at inducing desensitisation to allergens and
induces sustained unresponsiveness (ie, clinical remission) in a subset of patients, but …

Food allergies are the result of immune responses that cause adverse reactions to foods.
Immune responses to foods may produce a spectrum of symptoms and disorders, including …

Emerging evidence suggests that the increasing prevalence of food allergies is associated
with compositional and functional changes in our gut microbiota. Microbiota-host …

The gut-associated lymphoid tissue (GALT) faces a considerable challenge. It encounters
antigens derived from an estimated 1014 commensal microbes and greater than 30 kg of …

Highlights•Increased food allergy prevalence is being matched with research translation to
the clinic.•Identification of modifiable risk factors is leading to effective prevention …

The achievement of long‐lasting, safe treatments for food allergy is dependent on the
understanding of the immunological basis of food allergy. Accurate diagnosis is essential for …

Oral immunotherapy (OIT) provides an active treatment option for patients with food
allergies. OIT may improve quality of life and raise the threshold at which a patient with food …

Anaphylaxis is a systemic hypersensitivity reaction that can be life threatening.
Mechanistically, it results from the immune activation and release of a variety of mediators …