With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Cellular senescence is a key component of human aging that can be induced by a range of
stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of …

The chronic use of glucocorticoids decreases bone mass and quality and increases bone-
marrow adiposity, but the underlying mechanisms remain unclear. Here, we show that bone …

Cellular senescence is a stress response associated with aging and disease, including
cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology …

Cellular senescence is a stress response elicited by different molecular insults. Senescence
results in cell cycle exit and is characterised by multiple phenotypic changes such as the …

The limitation of cancer radiotherapy does not derive from an inability to ablate tumor, but
rather to do so without excessively damaging critical tissues and organs and adversely …

Currently, the typical combination therapy of programmed death ligand‐1 (PD‐L1)
antibodies with radiotherapy (RT) still exhibits impaired immunogenic antitumor response in …

Synthetic glucocorticoids (GCs), one of the most effective treatments for chronic inflammatory
and autoimmune conditions in children, have adverse effects on the growing skeleton. GCs …

Cancer cell radioresistance is the primary cause of the decreased curability of non–small
cell lung cancer (NSCLC) observed in patients receiving definitive radiotherapy (RT) …

Advances in radiation techniques have enabled the precise delivery of higher doses of
radiotherapy to tumours, while sparing surrounding healthy tissues. Consequently, the …