Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of
extracellular amyloid-β (Aβ)-containing plaques followed by the formation of neurofibrillary …

Alzheimer's disease (AD) is the leading cause of dementia. The two histopathological
markers of AD are amyloid plaques composed of the amyloid-β (Aβ) peptide, and …

Mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to
increased Alzheimer's disease (AD) risk. Neurobiological functions of TREM2 and its …

Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …

Alzheimer's disease (AD) is defined as a severe chronic degenerative neurological disease
in human. The pathogenic mechanism of AD has been convincingly elucidated by the …

Objective Gut microbiota changes before the onset of Alzheimer's disease (AD) and the
alterations could be detected in the stage of mild cognitive impairment (MCI). The findings …

Several heterozygous missense mutations in the triggering receptor expressed on myeloid
cells 2 (TREM2) have recently been linked to risk for a number of neurological disorders …

TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other
neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor
genetically linked to the risk for Alzheimer's disease (AD). A proteolytic product, soluble …

Neurodegenerative diseases of the central nervous system progressively rob patients of
their memory, motor function, and ability to perform daily tasks. Advances in genetics and …