EMP1, EMP 2, and EMP3 as novel therapeutic targets in human cancer

YW Wang, HL Cheng, YR Ding, LH Chou… - Biochimica et Biophysica …, 2017 - Elsevier
The epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, and EMP3) belong to the
peripheral myelin protein 22-kDa (PMP22) gene family, which consists of at least seven …

Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers

N Zhang, HP Zhu, W Huang, X Wen, X **e… - … hematology & oncology, 2022 - Springer
Abstract Peripheral myelin protein 22 (PMP22) and epithelial membrane proteins (EMP-1,-2,
and-3) belong to a small hydrophobic membrane protein subfamily, with four …

Cancer-associated fibroblasts (CAFs) gene signatures predict outcomes in breast and prostate tumor patients

M Talia, E Cesario, F Cirillo, D Scordamaglia… - Journal of Translational …, 2024 - Springer
Background Over the last two decades, tumor-derived RNA expression signatures have
been developed for the two most commonly diagnosed tumors worldwide, namely prostate …

89Zr-ImmunoPET for the Specific Detection of EMP2-Positive Tumors

AM Chan, T Olafsen, J Tsui, FB Salazar… - Molecular Cancer …, 2024 - aacrjournals.org
Abstract Epithelial membrane protein-2 (EMP2) is upregulated in a number of tumors and
therefore remains a promising target for mAb-based therapy. In the current study, image …

A-to-I RNA editing shows dramatic up-regulation in osteosarcoma and broadly regulates tumor-related genes by altering microRNA target regions

F Ge, X Cao, Y Jiang - Journal of Applied Genetics, 2023 - Springer
Abstract A-to-I RNA editing is a prevalent type of RNA modification in animals. The
dysregulation of RNA editing has led to multiple human cancers. However, the role of RNA …

A novel model to combine clinical and pathway-based transcriptomic information for the prognosis prediction of breast cancer

S Huang, C Yee, T Ching, H Yu… - PLoS computational …, 2014 - journals.plos.org
Breast cancer is the most common malignancy in women worldwide. With the increasing
awareness of heterogeneity in breast cancers, better prediction of breast cancer prognosis is …

[HTML][HTML] The pivotal roles of the epithelial membrane protein family in cancer invasiveness and metastasis

MKB Ahmat Amin, A Shimizu, H Ogita - Cancers, 2019 - mdpi.com
The members of the family of epithelial membrane proteins (EMPs), EMP1, EMP2, and
EMP3, possess four putative transmembrane domain structures and are composed of …

Chromatin interaction networks revealed unique connectivity patterns of broad H3K4me3 domains and super enhancers in 3D chromatin

A Thibodeau, EJ Márquez, DG Shin, P Vera-Licona… - Scientific Reports, 2017 - nature.com
Broad domain promoters and super enhancers are regulatory elements that govern cell-
specific functions and harbor disease-associated sequence variants. These elements are …

[HTML][HTML] Epithelial membrane protein 2 suppresses non-small cell lung cancer cell growth by inhibition of MAPK pathway

Y Ma, DC Schröder, M Nenkov, MN Rizwan… - International journal of …, 2021 - mdpi.com
Epithelial membrane proteins (EMP1-3) are involved in epithelial differentiation and
carcinogenesis. Dysregulated expression of EMP2 was observed in various cancers, but its …

Integrating the characteristic genes of macrophage pseudotime analysis in single-cell RNA-seq to construct a prediction model of atherosclerosis

Z Tian, S Yang - Aging (Albany Ny), 2023 - pmc.ncbi.nlm.nih.gov
Background: Macrophages play an important role in the occurrence and development of
atherosclerosis. However, few existing studies have deliberately analyzed the changes in …