The imprecise nature of psychiatric nosology restricts progress towards characterizing and
treating mental health disorders. One issue is the 'heterogeneity problem': different causal …

The direct and indirect pathway striatal medium spiny neurons (dMSNs and iMSNs) have
long been linked to action selection, but the precise roles of these neurons in this process …

In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

Background Depression is a growing global problem with significant individual and societal
costs. Despite their consequences, depressive symptoms are poorly recognized and …

Mental illnesses are becoming increasingly prevalent, in turn leading to an increased
interest in exploring artificial intelligence (AI) solutions to facilitate and enhance healthcare …

Mental disorders cause a significant degree of burden to affected individuals and to society
at large. Reasons for this are their high prevalence (one in every two people suffers from a …

Anxiety disorders are prevalent and highly disabling mental disorders. In recent years,
intensive efforts focused on the search for potential neuroimaging, genetic, and peripheral …

Psychiatric illnesses are cognitive and behavioral disorders of the brain. At present,
psychiatric diagnosis is based on DSM-5 criteria. Even if endophenotype specificity for …

Abstract Background The American Heart Association Life's Simple 7 (LS7) is a composite
metric assessing cardiovascular health on a scale of 0–14 comprised of nutrition, physical …

Objective This study tests associations of DNA methylation-based (DNAm) measures of
epigenetic age acceleration (EAA) with cross-sectional and longitudinal depressive …