[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …
Synaptic degeneration in Alzheimer disease
Alzheimer disease (AD) is characterized by progressive cognitive decline in older
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
individuals accompanied by the presence of two pathological protein aggregates—amyloid …
[HTML][HTML] A human brain vascular atlas reveals diverse mediators of Alzheimer's risk
The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …
disability and death, and the specialized structure it forms—the blood–brain barrier …
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
JJ Iliff, M Wang, Y Liao, BA Plogg, W Peng… - Science translational …, 2012 - science.org
Because it lacks a lymphatic circulation, the brain must clear extracellular proteins by an
alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain …
alternative mechanism. The cerebrospinal fluid (CSF) functions as a sink for brain …
The gut microbiome in Alzheimer's disease: what we know and what remains to be explored
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …
sustained decline in cognition. There are currently few effective disease modifying therapies …
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Abstract Apolipoprotein E (Apo-E) is a major cholesterol carrier that supports lipid transport
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
and injury repair in the brain. APOE polymorphic alleles are the main genetic determinants …
Forty-hertz light stimulation does not entrain native gamma oscillations in Alzheimer's disease model mice
There is a demand for noninvasive methods to ameliorate disease. We investigated whether
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …
40-Hz flickering light entrains gamma oscillations and suppresses amyloid-β in the brains of …
The glymphatic system: a beginner's guide
NA Jessen, ASF Munk, I Lundgaard… - Neurochemical …, 2015 - Springer
The glymphatic system is a recently discovered macroscopic waste clearance system that
utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote …
utilizes a unique system of perivascular tunnels, formed by astroglial cells, to promote …
Clearance systems in the brain—implications for Alzheimer disease
Accumulation of toxic protein aggregates—amyloid-β (Aβ) plaques and
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …
hyperphosphorylated tau tangles—is the pathological hallmark of Alzheimer disease (AD) …
Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
CR Jack, DS Knopman, WJ Jagust… - The lancet …, 2013 - thelancet.com
In 2010, we put forward a hypothetical model of the major biomarkers of Alzheimer's disease
(AD). The model was received with interest because we described the temporal evolution of …
(AD). The model was received with interest because we described the temporal evolution of …