RNA in cancer

GJ Goodall, VO Wickramasinghe - Nature Reviews Cancer, 2021 - nature.com
While the processing of mRNA is essential for gene expression, recent findings have
highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …

Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

Opportunities and obstacles for deep learning in biology and medicine

T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …

The current state and future directions of RNAi-based therapeutics

RL Setten, JJ Rossi, S Han - Nature reviews Drug discovery, 2019 - nature.com
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology

L Chang, G Zhou, O Soufan, J **a - Nucleic acids research, 2020 - academic.oup.com
Abstract miRNet is an easy-to-use, web-based platform designed to help elucidate
microRNA (miRNA) functions by integrating users' data with existing knowledge via network …

Noncoding RNA: RNA regulatory networks in cancer

JJ Chan, Y Tay - International journal of molecular sciences, 2018 - mdpi.com
Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This
largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and …

Post-transcriptional control of miRNA biogenesis

G Michlewski, JF Cáceres - Rna, 2019 - rnajournal.cshlp.org
MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage

H Wang, R Peng, J Wang, Z Qin, L Xue - Clinical epigenetics, 2018 - Springer
MicroRNAs are endogenous single-stranded non-coding small RNA molecules that can be
secreted into the circulation and exist stably. They usually exhibit aberrant expression under …

RNA structural dynamics as captured by molecular simulations: a comprehensive overview

J Sponer, G Bussi, M Krepl, P Banáš, S Bottaro… - Chemical …, 2018 - ACS Publications
With both catalytic and genetic functions, ribonucleic acid (RNA) is perhaps the most
pluripotent chemical species in molecular biology, and its functions are intimately linked to …

Regulatory network of miRNA on its target: coordination between transcriptional and post-transcriptional regulation of gene expression

M Pu, J Chen, Z Tao, L Miao, X Qi, Y Wang… - Cellular and Molecular …, 2019 - Springer
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that participate in a
majority of biological processes via regulating target gene expression. The post …