Neuroinflammation is a physiological protective response in the context of infection and
injury. However, neuroinflammation, especially if chronic, may also drive …

DHEA and DHEAS are steroids synthesized in human adrenals, but their function is unclear.
In addition to adrenal synthesis, evidence also indicates that DHEA and DHEAS are …

This chapter provides an overview of neurosteroids, especially their impact on the brain, sex
differences and their therapeutic potentials. Neurosteroids are synthesized within the brain …

Steroids influence neuronal function through binding to cognate intracellular receptors
which may act as transcription factors in the regulation of gene expression. In addition …

The aim of this review was to examine the evidence for age-related changes of the
hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on …

In human beings of both sexes, dehydroepiandrosterone sulfate (DHEAS) circulating in
blood is mostly an adrenally secreted steroid whose serum concentration (in the micromolar …

Neurosteroids represent a class of endogenous steroids that are synthesized in the brain,
the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor …

This review briefly summarizes recent developments in our understanding of the role of
androgens in maintaining normal hippocampal structure. Studies in rats and vervet monkeys …

Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, exert multiple effects in the
rodent central nervous system (CNS). Most of them seem to be mediated through their non …

Aging is a general process of functional decline which involves in particular a decline of
cognitive abilities. However, the severity of this decline differs from one subject to another …