Adrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable
prognosis. Here we summarize the knowledge about diagnosis, epidemiology …

Oxysterols are cholesterol metabolites that can be produced through enzymatic or radical
processes. They constitute a large family of lipids (ie the oxysterome) involved in a plethora …

Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic
biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and …

There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …

Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Drug discovery and development involve the utilization of in vitro and in vivo experimental
models. Different models, ranging from test tube experiments to cell cultures, animals …

Targeted concurrent inhibition of intestinal drug efflux transporter P-glycoprotein (P-gp) and
drug metabolizing enzyme cytochrome P450 3A4 (CYP3A4) is a promising approach to …

A microemulsion system of docetaxel was prepared and evaluated for its solubilization
capacity and oral bioavailability improvement. Based on a solubility study and pseudo …

Oral administration is the most commonly used route for drug treatment. Intestinal
cytochrome P450 (CYP)-mediated metabolism can eliminate a large proportion of some …

Paclitaxel, a potential anticancer agent against solid tumors has been restricted from its oral
use due to poor water solubility as well as Pgp efflux property. The present study was aimed …