The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease
Protein phosphorylation regulates many cellular processes by causing changes in protein
conformation. The prolyl isomerase PIN1 has been identified as a regulator of …
conformation. The prolyl isomerase PIN1 has been identified as a regulator of …
The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target
Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …
against solid tumours, largely because of the activation of heterogeneous oncogenic …
Ligand-Controlled C(sp3)–H Arylation and Olefination in Synthesis of Unnatural Chiral α–Amino Acids
The use of ligands to tune the reactivity and selectivity of transition metal catalysts for C (sp3)–
H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we …
H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we …
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
A common key regulator of oncogenic signaling pathways in multiple tumor types is the
unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and …
unique isomerase Pin1. However, available Pin1 inhibitors lack the required specificity and …
[HTML][HTML] Nonnatural amino acid synthesis by using carbon-hydrogen bond functionalization methodology
LD Tran, O Daugulis - Angewandte Chemie (International ed. in …, 2012 - ncbi.nlm.nih.gov
During the last years, transition-metal-catalyzed carbon-hydrogen bond functionalization
has witnessed an explosive growth.[1] The use of CH bond as a functional group is …
has witnessed an explosive growth.[1] The use of CH bond as a functional group is …
Prolyl isomerase Pin1 in cancer
Proline-directed phosphorylation is a posttranslational modification that is instrumental in
regulating signaling from the plasma membrane to the nucleus, and its dysregulation …
regulating signaling from the plasma membrane to the nucleus, and its dysregulation …
PIN1, the cell cycle and cancer
ES Yeh, AR Means - Nature Reviews Cancer, 2007 - nature.com
PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and
so affect protein function and/or stability. PIN1 regulates a number of proteins important for …
so affect protein function and/or stability. PIN1 regulates a number of proteins important for …
Biological function of Pin1 in vivo and its inhibitors for preclinical study: Early development, current strategies, and future directions
S He, L Li, R **, X Lu - Journal of Medicinal Chemistry, 2023 - ACS Publications
Peptidyl-prolyl cis/trans isomerase family (PPIase) is structurally divided into three
subfamilies, cyclophilins (Cyps), FK506-binding proteins (FKBPs), and parvulins. Pin1 …
subfamilies, cyclophilins (Cyps), FK506-binding proteins (FKBPs), and parvulins. Pin1 …
Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease
Phosphorylation of proteins on serine or threonine residues preceding proline is a key
signalling mechanism in diverse physiological and pathological processes. Pin1 (peptidyl …
signalling mechanism in diverse physiological and pathological processes. Pin1 (peptidyl …
Peptidyl-proline isomerases (PPIases): targets for natural products and natural product-inspired compounds: miniperspective
Peptidyl-proline isomerases (PPIases) are a chaperone superfamily comprising the FK506-
binding proteins (FKBPs), cyclophilins, and parvulins. PPIases catalyze the cis/trans …
binding proteins (FKBPs), cyclophilins, and parvulins. PPIases catalyze the cis/trans …