One hundred years ago, Ramón y Cajal, considered by many as the founder of modern
neuroscience, stated that neurons of the adult central nervous system (CNS) are incapable …

Abstract Objects Traumatic spinal cord injury (TSCI) causes neurological dysfunction below
the injured segment of the spinal cord, which significantly impacts the quality of life in …

Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

Traumatic spinal cord injury (SCI) is a life changing neurological condition with substantial
socioeconomic implications for patients and their care-givers. Recent advances in medical …

Traumatic spinal cord injury results in severe and irreversible loss of function. The injury
triggers a complex cascade of inflammatory and pathological processes, culminating in …

Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating
damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI …

Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

All components of the CNS are surrounded by a diffuse extracellular matrix (ECM)
containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans …

Since no approved therapies to restore mobility and sensation following spinal cord injury
(SCI) currently exist, a better understanding of the cellular and molecular mechanisms …

Traumatic spinal cord injury (SCI) is a leading cause of lifelong disabilities. Permanent
sensory, motor and autonomic impairments after SCI are substantially attributed to …