Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
the elderly. The underlying mechanism of non-neovascular AMD (dry AMD), also named …

Essential polyunsaturated fatty acids (PUFAs) are critical nutritional lipids that must be
obtained from the diet to sustain homeostasis. Omega-3 and-6 PUFAs are key components …

The dysfunction and cell death of retinal pigment epithelial (RPE) cells are hallmarks of late-
stage dry (atrophic) age-related macular degeneration (AMD), for which no effective therapy …

Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

Purpose: To investigate the expression of humanin (HN) in human retinal pigment epithelial
(hRPE) cells and its effect on oxidative stress–induced cell death, mitochondrial …

Recent data have provided important clues about the molecular mechanisms underlying
certain retinal degenerative diseases, including retinitis pigmentosa and age-related …

Age-related macular degeneration (AMD) is the leading cause of blindness in the developed
world. It is a multifactorial disease, and current therapy predominantly limits damage only …

Oxidative stress occurs when the level of prooxidants exceeds the level of antioxidants in
cells resulting in oxidation of cellular components and consequent loss of cellular function …

Methionine oxidation and reduction is a common phenomenon occurring in biological
systems under both physiological and oxidative-stress conditions. The levels of methionine …

Cysteine and methionine residues are the amino acids most sensitive to oxidation by
reactive oxygen species. However, in contrast to other amino acids, certain cysteine and …