Small heat shock proteins: Simplicity meets complexity
M Haslbeck, S Weinkauf, J Buchner - Journal of Biological Chemistry, 2019 - ASBMB
Small heat shock proteins (sHsps) are a ubiquitous and ancient family of ATP-independent
molecular chaperones. A key characteristic of sHsps is that they exist in ensembles of iso …
molecular chaperones. A key characteristic of sHsps is that they exist in ensembles of iso …
A first line of stress defense: small heat shock proteins and their function in protein homeostasis
M Haslbeck, E Vierling - Journal of molecular biology, 2015 - Elsevier
Small heat shock proteins (sHsps) are virtually ubiquitous molecular chaperones that can
prevent the irreversible aggregation of denaturing proteins. sHsps complex with a variety of …
prevent the irreversible aggregation of denaturing proteins. sHsps complex with a variety of …
[HTML][HTML] Small heat shock proteins: role in cellular functions and pathology
Small heat shock proteins (sHsps) are conserved across species and are important in stress
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …
tolerance. Many sHsps exhibit chaperone-like activity in preventing aggregation of target …
Cellular functions and mechanisms of action of small heat shock proteins
A Mogk, C Ruger-Herreros… - Annual review of …, 2019 - annualreviews.org
Small heat shock proteins (sHsps) constitute a diverse chaperone family that shares the α-
crystallin domain, which is flanked by variable, disordered N-and C-terminal extensions …
crystallin domain, which is flanked by variable, disordered N-and C-terminal extensions …
Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation
Protein phase separation drives the assembly of membraneless organelles, but little is
known about how these membraneless organelles are maintained in a metastable liquid-or …
known about how these membraneless organelles are maintained in a metastable liquid-or …
Heat shock proteins regulatory role in neurodevelopment
DJ Miller, PE Fort - Frontiers in neuroscience, 2018 - frontiersin.org
Heat shock proteins (Hsps) are a large family of molecular chaperones that are well-known
for their roles in protein maturation, re-folding and degradation. While some Hsps are …
for their roles in protein maturation, re-folding and degradation. While some Hsps are …
Small heat shock proteins, big impact on protein aggregation in neurodegenerative disease
JM Webster, AL Darling, VN Uversky… - Frontiers in …, 2019 - frontiersin.org
Misfolding, aggregation, and aberrant accumulation of proteins are central components in
the progression of neurodegenerative disease. Cellular molecular chaperone systems …
the progression of neurodegenerative disease. Cellular molecular chaperone systems …
[HTML][HTML] The growing world of small heat shock proteins: from structure to functions
Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental
roles in cell biology. sHSPs are key components of the cellular protein quality control …
roles in cell biology. sHSPs are key components of the cellular protein quality control …
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity
A major role for the intracellular post-translational modification O-GlcNAc appears to be the
inhibition of protein aggregation. Most of the previous studies in this area focused on O …
inhibition of protein aggregation. Most of the previous studies in this area focused on O …
Small heat-shock proteins: important players in regulating cellular proteostasis
Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone
proteins that play a critical role in mitigating and preventing protein aggregation under stress …
proteins that play a critical role in mitigating and preventing protein aggregation under stress …