The immune response to Candida species is shaped by the commensal character of the
fungus. There is a crucial role for discerning between colonization and invasion at mucosal …

A comprehensive understanding of host–pathogen interactions requires a knowledge of the
associated gene expression changes in both the pathogen and the host. Traditional, probe …

The transcriptome is a powerful proxy for the physiological state of a cell, healthy or
diseased. As a result, transcriptome analysis has become a key tool in understanding the …

Advances in transcriptome sequencing allow for simultaneous interrogation of differentially
expressed genes from multiple species originating from a single RNA sample, termed dual …

Background The soluble pattern-recognition receptor known as long pentraxin 3 (PTX3) has
a nonredundant role in antifungal immunity. The contribution of single-nucleotide …

Vaginal candidiasis is an extremely common disease predominantly caused by four
phylogenetically diverse species: Candida albicans; Candida glabrata; Candida …

The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as
a harmless commensal, but frequently causes infections under certain predisposing …

The incidence of opportunistic yeast infections in humans has been increasing over recent
years. These infections are difficult to treat and diagnose, in part due to the large number …

Aspergillus fumigatus is an environmental filamentous fungus that also acts as an
opportunistic pathogen able to cause a variety of symptoms, from an allergic response to a …

Background Streptococcus pneumoniae, the pneumococcus, is the main etiological agent of
pneumonia. Pneumococcal infection is initiated by bacterial adherence to lung epithelial …