Heterodimeric cap** protein (CP/CapZ) is an essential factor for the assembly of branched
actin networks, which push against cellular membranes to drive a large variety of cellular …
actin networks, which push against cellular membranes to drive a large variety of cellular …
Mechanism of synergistic activation of Arp2/3 complex by cortactin and WASP-family proteins
FE Fregoso, M Boczkowska, G Rebowski… - Nature …, 2023 - nature.com
Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …
Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change
Summary Actin-related protein 2/3 (Arp2/3) complex is a seven-subunit assembly that
nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to …
nucleates branched actin filaments. Small molecule inhibitors CK-666 and CK-869 bind to …
The Arp2/3 regulatory system and its deregulation in cancer
N Molinie, A Gautreau - Physiological reviews, 2018 - journals.physiology.org
The Arp2/3 complex is an evolutionary conserved molecular machine that generates
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
branched actin networks. When activated, the Arp2/3 complex contributes the actin …
The centrosome is an actin-organizing centre
Microtubules and actin filaments are the two main cytoskeleton networks supporting
intracellular architecture and cell polarity. The centrosome nucleates and anchors …
intracellular architecture and cell polarity. The centrosome nucleates and anchors …
Structure of Arp2/3 complex at a branched actin filament junction resolved by single-particle cryo-electron microscopy
B Ding, HY Narvaez-Ortiz, Y Singh… - Proceedings of the …, 2022 - National Acad Sciences
Arp2/3 complex nucleates branched actin filaments that provide pushing forces to drive
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …
cellular processes such as lamellipodial protrusion and endocytosis. Arp2/3 complex is …