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Strategies to inhibit entry of HBV and HDV into hepatocytes
Although there has been much research into the pathogenesis and treatment of hepatitis B
virus (HBV) and hepatitis D virus (HDV) infections, we still do not completely understand …
virus (HBV) and hepatitis D virus (HDV) infections, we still do not completely understand …
Transmembrane transport of endo-and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …
New insights in bilirubin metabolism and their clinical implications
E Sticova, M Jirsa - World Journal of Gastroenterology: WJG, 2013 - pmc.ncbi.nlm.nih.gov
Bilirubin, a major end product of heme breakdown, is an important constituent of bile,
responsible for its characteristic colour. Over recent decades, our understanding of bilirubin …
responsible for its characteristic colour. Over recent decades, our understanding of bilirubin …
[PDF][PDF] Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver
An important function of hepatocytes is the biotransformation and elimination of various
drugs, many of which are organic cations and are taken up by organic cation transporters …
drugs, many of which are organic cations and are taken up by organic cation transporters …
The role of the sodium-taurocholate cotransporting polypeptide (NTCP) and of the bile salt export pump (BSEP) in physiology and pathophysiology of bile formation
B Stieger - Drug transporters, 2011 - Springer
Bile formation is an important function of the liver. Bile salts are a major constituent of bile
and are secreted by hepatocytes into bile and delivered into the small intestine, where they …
and are secreted by hepatocytes into bile and delivered into the small intestine, where they …
The apical conjugate efflux pump ABCC2 (MRP2)
ABCC2 is a member of the multidrug resistance protein subfamily localized exclusively to
the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule …
the apical membrane domain of polarized cells, such as hepatocytes, renal proximal tubule …
Expression and immunolocalization of the multidrug resistance proteins, MRP1–MRP6 (ABCC1–ABCC6), in human brain
Multidrug resistance proteins (MRPs, symbol ABCC) are membrane glycoproteins that
mediate the ATP-dependent export of organic anions, including cytotoxic and antiviral drugs …
mediate the ATP-dependent export of organic anions, including cytotoxic and antiviral drugs …
Estimation of liver function using T1 map** on Gd-EOB-DTPA-enhanced magnetic resonance imaging
T Katsube, M Okada, S Kumano, M Hori… - Investigative …, 2011 - journals.lww.com
Objectives: To investigate the ability of T1 map** of liver on gadolinium ethoxybenzyl
diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance …
diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance …
Ursodeoxycholic acid in cholestasis: linking action mechanisms to therapeutic applications
MG Roma, FD Toledo, AC Boaglio, CL Basiglio… - Clinical …, 2011 - portlandpress.com
UDCA (ursodeoxycholic acid) is the therapeutic agent most widely used for the treatment of
cholestatic hepatopathies. Its use has expanded to other kinds of hepatic diseases, and …
cholestatic hepatopathies. Its use has expanded to other kinds of hepatic diseases, and …
[HTML][HTML] Principles of hepatic organic anion transporter regulation during cholestasis, inflammation and liver regeneration
Hepatic uptake and biliary excretion of organic anions (eg, bile acids and bilirubin) is
mediated by hepatobiliary transport systems. Defects in transporter expression and function …
mediated by hepatobiliary transport systems. Defects in transporter expression and function …