A comprehensive review and update on the pathogenesis of inflammatory bowel disease

Q Guan - Journal of immunology research, 2019 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic and life‐threating inflammatory disease of
gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis …

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

LW Peterson, D Artis - Nature reviews immunology, 2014 - nature.com
The abundance of innate and adaptive immune cells that reside together with trillions of
beneficial commensal microorganisms in the mammalian gastrointestinal tract requires …

Immunopathogenesis of IBD: current state of the art

HSP De Souza, C Fiocchi - Nature reviews Gastroenterology & …, 2016 - nature.com
IBD is a chronic inflammatory condition of the gastrointestinal tract encompassing two main
clinical entities: Crohn's disease and ulcerative colitis. Although Crohn's disease and …

Inflammatory and microbiota-related regulation of the intestinal epithelial barrier

G Barbara, MR Barbaro, D Fuschi, M Palombo… - Frontiers in …, 2021 - frontiersin.org
The intestinal epithelial barrier (IEB) is one of the largest interfaces between the
environment and the internal milieu of the body. It is essential to limit the passage of harmful …

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

S Jalili-Firoozinezhad, FS Gazzaniga… - Nature biomedical …, 2019 - nature.com
The diverse bacterial populations that comprise the commensal microbiome of the human
intestine play a central role in health and disease. A method that sustains complex microbial …

Intestinal barrier and gut microbiota: Sha** our immune responses throughout life

T Takiishi, CIM Fenero, NOS Câmara - Tissue barriers, 2017 - Taylor & Francis
The gastrointestinal (GI) tract is considered the largest immunological organ in the body
having a central role in regulating immune homeostasis. Contrary to earlier belief, the …

Dendritic cell migration in health and disease

T Worbs, SI Hammerschmidt, R Förster - Nature Reviews Immunology, 2017 - nature.com
Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

JL Coombes, KRR Siddiqui… - The Journal of …, 2007 - rupress.org
Foxp3+ regulatory T (T reg) cells play a key role in controlling immune pathological re
actions. Many develop their regulatory activity in the thymus, but there is also evidence for …

Observation of Floquet-Bloch states on the surface of a topological insulator

YH Wang, H Steinberg, P Jarillo-Herrero, N Gedik - Science, 2013 - science.org
The unique electronic properties of the surface electrons in a topological insulator are
protected by time-reversal symmetry. Circularly polarized light naturally breaks time-reversal …

Epithelial Toll-like receptors and their role in gut homeostasis and disease

JF Burgueño, MT Abreu - Nature Reviews Gastroenterology & …, 2020 - nature.com
The human gastrointestinal tract is colonized by trillions of microorganisms that interact with
the host to maintain structural and functional homeostasis. Acting as the interface between …