[HTML][HTML] Hypoxia and brain aging: Neurodegeneration or neuroprotection?
The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …
Hypoxia-inducible factors and obstructive sleep apnea
NR Prabhakar, YJ Peng… - The Journal of clinical …, 2020 - Am Soc Clin Investig
Intermittent hypoxia (IH) is a hallmark manifestation of obstructive sleep apnea (OSA), a
widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible …
widespread disorder of breathing. This Review focuses on the role of hypoxia-inducible …
Neurocognitive impairment in obstructive sleep apnea
C Lal, C Strange, D Bachman - Chest, 2012 - Elsevier
Obstructive sleep apnea syndrome (OSAS) is a common disorder with far-reaching health
implications. One of the major consequences of OSAS is an impact on neurocognitive …
implications. One of the major consequences of OSAS is an impact on neurocognitive …
BDNF therapeutic mechanisms in neuropsychiatric disorders
Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult
brain and functions as both a primary neurotrophic signal and a neuromodulator. It serves …
brain and functions as both a primary neurotrophic signal and a neuromodulator. It serves …
Activity-dependent, stress-responsive BDNF signaling and the quest for optimal brain health and resilience throughout the lifespan
SM Rothman, MP Mattson - Neuroscience, 2013 - Elsevier
During development of the nervous system, the formation of connections (synapses)
between neurons is dependent upon electrical activity in those neurons, and neurotrophic …
between neurons is dependent upon electrical activity in those neurons, and neurotrophic …
The effects of hypoxia and inflammation on synaptic signaling in the CNS
Normal brain function is highly dependent on oxygen and nutrient supply and when the
demand for oxygen exceeds its supply, hypoxia is induced. Acute episodes of hypoxia may …
demand for oxygen exceeds its supply, hypoxia is induced. Acute episodes of hypoxia may …
The role of inflammation, hypoxia, and opioid receptor expression in pain modulation in patients suffering from obstructive sleep apnea
Obstructive sleep apnea (OSA) is a relatively common disease in the general population.
Besides its interaction with many comorbidities, it can also interact with potentially painful …
Besides its interaction with many comorbidities, it can also interact with potentially painful …
Unexpected benefits of intermittent hypoxia: enhanced respiratory and nonrespiratory motor function
Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-
disordered breathing, including central nervous system pathology. However, recent …
disordered breathing, including central nervous system pathology. However, recent …
Long-term potentiation at CA3–CA1 hippocampal synapses with special emphasis on aging, disease, and stress
A Kumar - Frontiers in aging neuroscience, 2011 - frontiersin.org
Synaptic plasticity in the mammalian central nervous system has been the subject of intense
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …
investigation for the past four decades. Long-term potentiation (LTP), a major reflection of …
TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory
The neurotrophin brain-derived neurotrophic factor (BDNF) and its receptor TrkB participate
in diverse neuronal functions, including activity-dependent synaptic plasticity that is crucial …
in diverse neuronal functions, including activity-dependent synaptic plasticity that is crucial …