There is an increasing momentum in research and pharmaceutical industry communities to
design sustained, non-invasive delivery systems to treat chronic neovascular ocular …

The success of antibody therapeutics is strongly influenced by their multifunctional nature
that couples antigen recognition mediated by their variable regions with effector functions …

Therapeutic monoclonal antibodies and related products have steadily grown to become the
dominant product class within the biopharmaceutical market. Production of antibodies …

Established monoclonal antibodies (mAbs) allow treatment of cancers, autoimmune
diseases and other severe illnesses. Side effects either arise due to interaction with the …

Biologicals are important ocular drugs that are be delivered using monthly and bimonthly
intravitreal injections to treat retinal diseases, such as age-related macular degeneration …

Innovative protein engineering and chemical conjugation technologies have yielded an
impressive number of drug candidates in clinical development including> 80 antibody drug …

Nanolipoprotein particles (NLPs), a lipid bilayer-based nanoparticle platform, have recently
been developed for in vivo delivery of a variety of molecules of therapeutic interest, but their …

Deamidation evaluation and mitigation is an important aspect of therapeutic antibody
developability assessment. We investigated the structure and function of the Asn-Gly …

Purpose To evaluate the stability of a model Mab1 and Fab1 under in vitro vitreal conditions
in the presence of various metabolites and in the presence of light at λ> 400 nM. Methods A …

Highlights•Current treatments for AMD and the need for LAD are summarized.•Key
considerations for development of LAD technologies are detailed.•Currently marketed …