Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis

Q Cai, SC Verma, J Lu, ES Robertson - Advances in virus research, 2010 - Elsevier
Abstract Kaposi's Sarcoma-associated Herpesvirus (KSHV), also known as human
herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated …

A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus …

J Hellert, M Weidner-Glunde, J Krausze… - PLoS …, 2013 - journals.plos.org
Kaposi sarcoma-associated herpesvirus (KSHV) establishes a lifelong latent infection and
causes several malignancies in humans. Murine herpesvirus 68 (MHV-68) is a related γ2 …

Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection

C Sattler, F Moritz, S Chen, B Steer, D Kutschke… - Particle and fibre …, 2017 - Springer
Background Inhalation of environmental (nano) particles (NP) as well as persistent
herpesvirus-infection are potentially associated with chronic lung disease and as both are …

A Mouse Model to Study the Pathogenesis of γ-herpesviral Infections in Germinal Center B Cells

U Rambold, S Sperling, Z Chew, Y Wang, B Steer… - Cells, 2023 - mdpi.com
CD30-positive germinal center (GC)-derived B cell lymphomas are frequently linked to
Epstein–Barr Virus (EBV) infection. However, a suitable animal model for the investigation of …

Open reading frames M12/M13 jointly contribute to MHV-68 latency

B Steer, B Adler, H Adler - Journal of General Virology, 2023 - microbiologyresearch.org
Murine gammaherpesvirus 68 (MHV-68), a widely used small-animal model for the analysis
of gammaherpesvirus pathogenesis, encodes the MHV-68-specific ORFs M12 and M13. The …

The small noncoding RNAs (sncRNAs) of murine gammaherpesvirus 68 (MHV-68) are involved in regulating the latent-to-lytic switch in vivo

B Steer, M Strehle, C Sattler, D Bund, B Flach… - Scientific Reports, 2016 - nature.com
Abstract The human gammaherpesviruses Epstein-Barr virus (EBV) and Kaposi's sarcoma-
associated herpesvirus (KSHV), which are associated with a variety of diseases including …

Multiple lytic origins of replication are required for optimal gammaherpesvirus fitness in vitro and in vivo

C Sattler, B Steer, H Adler - PLoS Pathogens, 2016 - journals.plos.org
An unresolved question in herpesvirus biology is why some herpesviruses contain more
than one lytic origin of replication (oriLyt). Using murine gammaherpesvirus 68 (MHV-68) as …

ORF6 and ORF61 expressing MVA vaccines impair early but not late latency in murine gammaherpesvirus MHV-68 infection

B Samreen, S Tao, K Tischer, H Adler… - Frontiers in …, 2019 - frontiersin.org
Gammaherpesviruses (γHV) are important pathogens causing persistent infections which
lead to several malignancies in immunocompromised patients. Murine γHV 68 (MHV-68), a …

Initiation of lytic DNA replication in Epstein–Barr virus: search for a common family mechanism

AJ Rennekamp, PM Lieberman - Future virology, 2010 - Taylor & Francis
Herpesviruses are a complex family of dsDNA viruses that are a major cause of human
disease. All family members share highly related viral replication proteins, such as DNA …

[HTML][HTML] Murine gammaherpesvirus 68 glycoprotein 150 does not contribute to latency amplification in vivo

R Ruiss, S Ohno, B Steer, R Zeidler, H Adler - Virology journal, 2012 - Springer
Murine gammaherpesvirus 68 (MHV-68) is used as a model to study the function of
gammaherpesvirus glycoproteins. gp150 of MHV-68, encoded by open reading frame M7, is …