Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
Hallmarks of brain aging: adaptive and pathological modification by metabolic states
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …
Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques
Autophagy is markedly impaired in Alzheimer's disease (AD). Here we reveal unique
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …
autophagy dysregulation within neurons in five AD mouse models in vivo and identify its …
Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology
Alzheimer's disease (AD) alters astrocytes, but the effect of Aß and Tau pathology is poorly
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …
understood. TRAP-seq translatome analysis of astrocytes in APP/PS1 ß-amyloidopathy and …
TREM2 maintains microglial metabolic fitness in Alzheimer's disease
Elevated risk of develo** Alzheimer's disease (AD) is associated with hypomorphic
variants of TREM2, a surface receptor required for microglial responses to …
variants of TREM2, a surface receptor required for microglial responses to …
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles
Autophagy is central to the maintenance of organismal homeostasis in both physiological
and pathological situations. Accordingly, alterations in autophagy have been linked to …
and pathological situations. Accordingly, alterations in autophagy have been linked to …
Compromised autophagy and neurodegenerative diseases
FM Menzies, A Fleming, DC Rubinsztein - Nature Reviews …, 2015 - nature.com
Most neurodegenerative diseases that afflict humans are associated with the
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …
intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial …
The role of autophagy in neurodegenerative disease
RA Nixon - Nature medicine, 2013 - nature.com
Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …
and eliminate damaged organelles and protein aggregates. These substrates reach …
A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome
FK Wiseman, T Al-Janabi, J Hardy… - Nature Reviews …, 2015 - nature.com
Down syndrome, which arises in individuals carrying an extra copy of chromosome 21, is
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that …
associated with a greatly increased risk of early-onset Alzheimer disease. It is thought that …
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
SB Chidambaram, MM Essa, AG Rathipriya… - Pharmacology & …, 2022 - Elsevier
The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …