Most swimming bacteria are capable of following gradients of nutrients, signaling molecules
and other environmental factors that affect bacterial physiology. This tactic behavior became …

Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have
been under development since the first whole-genome sequences appeared in the mid …

The rate of cell growth is crucial for bacterial fitness and drives the allocation of bacterial
resources, affecting, for example, the expression levels of proteins dedicated to metabolism …

Quantitative views of cellular functions require precise measures of rates of biomolecule
production, especially proteins—the direct effectors of biological processes. Here, we …

The prediction of cellular function from a genotype is a fundamental goal in biology. For
metabolism, constraint-based modelling methods systematize biochemical, genetic and …

The interspecies exchange of metabolites plays a key role in the spatiotemporal dynamics of
microbial communities. This raises the question of whether ecosystem-level behavior of …

Contrary to the textbook portrayal of glycolysis as a single pathway conserved across all
domains of life, not all sugar-consuming organisms use the canonical Embden–Meyerhoff …

Growth is a fundamental process of life. Growth requirements are well‐characterized
experimentally for many microbes; however, we lack a unified model for cellular growth …

Constraint-based models of metabolism are a widely used framework for predicting flux
distributions in genome-scale biochemical networks. The number of published methods for …

The reconstruction and analysis of genome-scale metabolic models constitutes a powerful
systems biology approach, with applications ranging from basic understanding of genotype …