[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

Beyond fibrinolysis: the confounding role of Lp (a) in thrombosis

MB Boffa - Atherosclerosis, 2022 - Elsevier
Elevated plasma concentrations of lipoprotein (a)(Lp (a)) are a causal risk factor for the
development of atherothrombotic disorders including coronary heart disease. However, the …

Aspirin for primary prevention of cardiovascular events in relation to lipoprotein (a) genotypes

P Lacaze, A Bakshi, M Riaz, G Polekhina… - Journal of the American …, 2022 - jacc.org
Background The role of aspirin in reducing lipoprotein (a)-mediated atherothrombotic events
in primary prevention is not established. Objectives This study sought to assess whether low …

Lipoprotein (a)—the crossroads of atherosclerosis, atherothrombosis and inflammation

S Ugovšek, M Šebeštjen - Biomolecules, 2021 - mdpi.com
Increased lipoprotein (a)(Lp (a)) levels are an independent predictor of coronary artery
disease (CAD), degenerative aortic stenosis (DAS), and heart failure independent of CAD …

LPA disruption with AAV-CRISPR potently lowers plasma apo (a) in transgenic mouse model: A proof-of-concept study

AM Doerfler, SH Park, JM Assini, A Youssef… - … Therapy Methods & …, 2022 - cell.com
Lipoprotein (a)(Lp (a)) represents a unique subclass of circulating lipoprotein particles and
consists of an apolipoprotein (a)(apo (a)) molecule covalently bound to apolipoprotein B …

Lipoprotein (a) in clinical practice: New perspectives from basic and translational science

CA Scipione, ML Koschinsky… - Critical reviews in clinical …, 2018 - Taylor & Francis
Elevated plasma concentrations of lipoprotein (a)(Lp (a)) are a causal risk factor for coronary
heart disease (CHD) and calcific aortic valve stenosis (CAVS). Genetic, epidemiological and …

[HTML][HTML] A Comprehensive Review of the Genetics of Dyslipidemias and Risk of Atherosclerotic Cardiovascular Disease

M Kalwick, M Roth - Nutrients, 2025 - mdpi.com
Dyslipidemias are often diagnosed based on an individual's lipid panel that may or may not
include Lp (a) or apoB. But these values alone omit key information that can underestimate …

[HTML][HTML] Lipoprotein (a) molar concentrations rather than genetic variants better predict coronary artery disease risk and severity in Han Chinese population

J Li, B Ma, Q Fang, J Wang, Y Sun… - Lipids in Health and …, 2025 - pmc.ncbi.nlm.nih.gov
Background It is well established that increased lipoprotein (a)[Lp (a)] is a significant risk
factor for coronary artery disease (CAD). Plasma Lp (a) levels are genetically determined …

Apolipoprotein (a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells

R Romagnuolo, K DeMarco, CA Scipione, MB Boffa… - Thrombosis …, 2018 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is an enigmatic lipoprotein which has been identified as a
causal risk factor for coronary heart disease and calcific aortic valve disease. Lp (a) consists …

[HTML][HTML] What is the role of aspirin in primary prevention in patients with elevated Lp (a)?

S Tsimikas - CardioMetabolic Syndrome Journal, 2023 - e-cmsj.org
Abstract Elevated lipoprotein (a)[Lp (a)] is an atherothrombotic risk factor associated with
increased risk of cardiovascular disease (CVD) and aortic stenosis. However, there are no …