The BET family in immunity and disease
Innate immunity serves as the rapid and first-line defense against invading pathogens, and
this process can be regulated at various levels, including epigenetic mechanisms. The …
this process can be regulated at various levels, including epigenetic mechanisms. The …
Targeting janus kinases and signal transducer and activator of transcription 3 to treat inflammation, fibrosis, and cancer: rationale, progress, and caution
U Bharadwaj, MM Kasembeli, P Robinson… - Pharmacological …, 2020 - Elsevier
Before it was molecularly cloned in 1994, acute-phase response factor or signal transducer
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
and activator of transcription (STAT) 3 was the focus of intense research into understanding …
Single-cell multi-omics identifies chronic inflammation as a driver of TP53-mutant leukemic evolution
Understanding the genetic and nongenetic determinants of tumor protein 53 (TP53)-
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …
mutation-driven clonal evolution and subsequent transformation is a crucial step toward the …
Somatic mutations and cell identity linked by Genoty** of Transcriptomes
Defining the transcriptomic identity of malignant cells is challenging in the absence of
surface markers that distinguish cancer clones from one another, or from admixed non …
surface markers that distinguish cancer clones from one another, or from admixed non …
Fedratinib, a newly approved treatment for patients with myeloproliferative neoplasm-associated myelofibrosis
M Talpaz, JJ Kiladjian - Leukemia, 2021 - nature.com
Myeloproliferative neoplasm (MPN)-associated myelofibrosis (MF) is characterized by
cytopenias, marrow fibrosis, constitutional symptoms, extramedullary hematopoiesis …
cytopenias, marrow fibrosis, constitutional symptoms, extramedullary hematopoiesis …
Molecular pathogenesis of the myeloproliferative neoplasms
The Philadelphia negative myeloproliferative neoplasms (MPN) compromise a
heterogeneous group of clonal myeloid stem cell disorders comprising polycythaemia vera …
heterogeneous group of clonal myeloid stem cell disorders comprising polycythaemia vera …
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis
Transcription and pre-mRNA splicing are key steps in the control of gene expression and
mutations in genes regulating each of these processes are common in leukaemia,. Despite …
mutations in genes regulating each of these processes are common in leukaemia,. Despite …
Inhibition of interleukin-1β reduces myelofibrosis and osteosclerosis in mice with JAK2-V617F driven myeloproliferative neoplasm
Abstract Interleukin-1β (IL-1β) is a master regulator of inflammation. Increased activity of IL-
1β has been implicated in various pathological conditions including myeloproliferative …
1β has been implicated in various pathological conditions including myeloproliferative …
Inflammatory pathophysiology as a contributor to myeloproliferative neoplasms
DAC Fisher, JS Fowles, A Zhou, ST Oh - Frontiers in immunology, 2021 - frontiersin.org
Myeloid neoplasms, including acute myeloid leukemia (AML), myeloproliferative neoplasms
(MPNs), and myelodysplastic syndromes (MDS), feature clonal dominance and remodeling …
(MPNs), and myelodysplastic syndromes (MDS), feature clonal dominance and remodeling …
MANIFEST: pelabresib in combination with ruxolitinib for Janus kinase inhibitor treatment-naive myelofibrosis
J Mascarenhas, M Kremyanskaya… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Standard therapy for myelofibrosis comprises Janus kinase inhibitors (JAKis), yet
spleen response rates of 30%-40%, high discontinuation rates, and a lack of disease …
spleen response rates of 30%-40%, high discontinuation rates, and a lack of disease …