Periodontitis, the sixth most prevalent epidemic disease globally, profoundly impacts oral
aesthetics and masticatory functionality. Hypoxia-inducible factor-1α (HIF-1α), an oxygen …

Pouchitis, as the most common complication after ileal pouch-anal anastomosis (IPAA), has
an incidence from 7% to 46%. Pouchitis treatment still represents one of the biggest gaps of …

Helicobacter pylori-induced inflammation is the strongest known risk factor for gastric
adenocarcinoma. Hypoxia-inducible factor-1 (HIF-1α) is a key transcriptional regulator of …

BACKGROUND: Clinical, nonspecific pouchitis is common after restorative proctocolectomy
for ulcerative colitis, but its cause is unknown. A possible lack of protection for the ileal …

Anastomotic leakage (AL) accounts for a major part of in-house mortality in patients
undergoing colorectal surgery. Local ischemia and abdominal sepsis are common risk …

Colitis-associated colorectal cancer (CAC) is a severe complication of inflammatory bowel
disease (IBD). HIF-prolyl hydroxylases (PHD1, PHD2, and PHD3) control cellular adaptation …

Ethnopharmacological relevance Ulcerative colitis (UC) is a chronic, non-specific
inflammatory disease affecting the colon and rectum with an etiology that remains elusive …

Background. Ischemia and reperfusion injury (IRI) determines primary allograft function after
liver transplantation (LT). Primary graft dysfunction (PGD) is associated with increased …

Liver fibrosis is characterized by excessive deposition of extracellular matrix due to chronic
inflammation of the liver. Hepatic stellate cells (HSCs) become activated and produce …

Egl-9 family hypoxia-inducible factor (egln), an oxygen-sensing enzyme family, has been
thoroughly characterized in mammals and certain fishes, but there is few research on its …