Immunoglobulins emerging from B lymphocytes and capable of recognizing almost all kinds
of antigens owing to the extreme diversity of their antigen‐binding portions, known as …

The development of B cells is dependent on the sequential DNA rearrangement of
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a …

B cell development is highly dependent on IL-7 receptor signaling mediated by IL-7
(Grabstein et al., 1993; Peschon et al., 1994; von Freeden-Jeffry et al., 1995; Puel et al …

Studies over the last decade uncovered overlap** niches for hematopoietic stem cells
(HSC s), multipotent progenitor cells, common lymphoid progenitors, and early B cell …

Hematopoiesis is regulated by signals from the microenvironment, transcription factor
networks, and changes of the epigenetic landscape. Transcription factors interact with and …

mTOR is an evolutionarily conserved kinase that plays a critical role in sensing and
responding to environmental determinants. Recent studies have shown that fine-tuning of …

Interleukin-7 (IL-7) drives early B lymphopoiesis, but the underlying molecular circuits
remain poorly understood, especially how Stat5 (signal transducer and activator of …

As the unique source of diverse immunoglobulin repertoires, B lymphocytes are an
indispensable part of humoral immunity. B cell progenitors progress through sequential and …

Precursor B lymphocytes expand upon expression of a pre‐B cell receptor (pre‐BCR), but
then transit into a resting state in which immunoglobulin light chain gene recombination is …

The adaptive immune system endows mammals with an ability to recognize nearly any
foreign invader through antigen receptors that are expressed on the surface of all …