GABA tone regulation and its cognitive functions in the brain
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
Chloride transporters controlling neuronal excitability
Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …
foundation of nervous system function. This inhibition is largely mediated by the …
[HTML][HTML] Spike frequency adaptation in neurons of the central nervous system
GE Ha, E Cheong - Experimental neurobiology, 2017 - ncbi.nlm.nih.gov
Neuronal firing patterns and frequencies determine the nature of encoded information of the
neurons. Here we discuss the molecular identity and cellular mechanisms of spike …
neurons. Here we discuss the molecular identity and cellular mechanisms of spike …
[HTML][HTML] The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?
Y Liu, Z Liu, KW Wang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Abstract Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca 2+ activated Cl–
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …
channels (CaCCs) that are critical for physiological functions, such as epithelial secretion …
The sixth transmembrane segment is a major gating component of the TMEM16A calcium-activated chloride channel
Calcium-activated chloride channels (CaCCs) formed by TMEM16A or TMEM16B are
broadly expressed in the nervous system, smooth muscles, exocrine glands, and other …
broadly expressed in the nervous system, smooth muscles, exocrine glands, and other …
On numerical approximations of fractional-order spiking neuron models
Fractional-order spiking neuron models can enrich model flexibility and dynamics due to the
extra degrees of freedom. This paper aims to study the effects of applying four different …
extra degrees of freedom. This paper aims to study the effects of applying four different …
Polymodal control of TMEM16x channels and scramblases
E Agostinelli, P Tammaro - International Journal of Molecular Sciences, 2022 - mdpi.com
The TMEM16A/anoctamin-1 calcium-activated chloride channel (CaCC) contributes to a
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …
range of vital functions, such as the control of vascular tone and epithelial ion transport. The …
Temperature effects on synaptic transmission and neuronal function in the visual thalamus
MJ Van Hook - PloS one, 2020 - journals.plos.org
Numerous neuronal properties including the synaptic vesicle release process,
neurotransmitter receptor complement, and postsynaptic ion channels are involved in …
neurotransmitter receptor complement, and postsynaptic ion channels are involved in …
Chloride homeostasis in neurons with special emphasis on the olivocerebellar system: differential roles for transporters and channels
N Rahmati, FE Hoebeek, S Peter… - Frontiers in cellular …, 2018 - frontiersin.org
The intraneuronal ionic composition is an important determinant of brain functioning. There
is growing evidence that aberrant homeostasis of the intracellular concentration of Cl−([Cl−] …
is growing evidence that aberrant homeostasis of the intracellular concentration of Cl−([Cl−] …
Intranasal delivery of cancer-targeting doxorubicin-loaded PLGA nanoparticles arrests glioblastoma growth
Glioblastoma multiforme (GBM) is the most aggressive form of brain tumour and treatment is
very challenging. Despite the recent advances in drug delivery systems, various approaches …
very challenging. Despite the recent advances in drug delivery systems, various approaches …