In many circumstances alternative courses of action and thoughts have to be inhibited to
allow the emergence of goal-directed behavior. However, this has not been the accepted …

α1-adrenergic receptors are G-Protein Coupled Receptors that are involved in
neurotransmission and regulate the sympathetic nervous system through binding and …

Schizophrenia is a complex and multifactorial disorder generally diagnosed in young adults
at the time of the first psychotic episode of delusions and hallucinations. These positive …

Modafinil is an FDA-approved eugeroic that directly increases cortical catecholamine levels,
indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels, and …

BACKGROUND: Modafinil, a putative cognitive enhancing drug, has previously been shown
to improve performance of healthy volunteers as well as patients with attention deficit …

Background Fatigue, cognitive deficits, and depression are frequently reported but often
undertreated symptoms that can profoundly affect daily life in patients with primary brain …

Schizophrenia is a life-long debilitating mental disorder affecting tens of millions of people
worldwide. The serendipitous discovery of antipsychotics focused pharmaceutical research …

Cognitive dysfunction in depression is associated with poorer clinical outcomes and
impaired psychosocial functioning. However, most treatments for depression do not …

Cognitive impairment is a core feature of schizophrenia, which is predictive for functional
outcomes and is, therefore, a treatment target in itself. Yet, literature on efficacy of different …

Today, there is continued, and in some cases growing, availability of not only psychoactive
substances, including treatments for mental health disorders such as cognitive enhancers …