Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

Gene transfer methods are promising in the field of gene therapy. Current methods for gene
transfer include three major groups: viral, physical and chemical methods. This review …

Recent developments in the application of micro-and nanosystems for drug administration
include a diverse range of new materials and methods. New approaches include the on …

Antimicrobial cationic peptides are of interest because they can combat multi-drug-resistant
microbes. Most peptides form α-helices or β-sheet-like structures that can insert into and …

Gene therapy provides great opportunities for treating diseases from genetic disorders,
infections and cancer. To achieve successful gene therapy, development of proper gene …

Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its
potential role in the treatment of acquired diseases such as cancer is now widely …

Utilization of unique acidic environment in various disease sites has been quite
advantageous in targeted drug delivery. Among the widely explored pH-sensitive moieties …

No Heading Polymeric gene delivery systems have been developed as an alternative for
viral gene delivery systems to overcome the problems in the use of viral gene carriers …

Cationic liposome–DNA complexes (lipoplexes) constitute a potentially viable alternative to
viral vectors for the delivery of therapeutic genes. This review will focus on various …

Polyethylenimine (PEI) is a gene carrier with high transfection efficiency. However, PEI has
high cytotoxicity, which depends on its molecular weight. To reduce the cytotoxicity …