Transition from acute to chronic pain after surgery
Over the past decade there has been an increasing reliance on strong opioids to treat acute
and chronic pain, which has been associated with a rising epidemic of prescription opioid …
and chronic pain, which has been associated with a rising epidemic of prescription opioid …
Trigeminal neuralgia: An overview from pathophysiology to pharmacological treatments
The trigeminal nerve (V) is the fifth and largest of all cranial nerves, and it is responsible for
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …
detecting sensory stimuli that arise from the craniofacial area. The nerve is divided into three …
Spatial transcriptomics reveals the distinct organization of mouse prefrontal cortex and neuronal subtypes regulating chronic pain
A Bhattacherjee, C Zhang, BR Watson… - Nature …, 2023 - nature.com
The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions
ranging from cognition, emotion and executive action to even pain processing. To decode …
ranging from cognition, emotion and executive action to even pain processing. To decode …
Assessment and manifestation of central sensitisation across different chronic pain conditions
Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …
important in the transition from acute to chronic pain and for diagnosis and development of …
[HTML][HTML] Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential
The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …
has received increasing attention. The gut microbiome is a crucial modulator of visceral …
Structural plasticity and reorganisation in chronic pain
Chronic pain is not simply a temporal continuum of acute pain. Studies on functional
plasticity in neural circuits of pain have provided mechanistic insights and linked various …
plasticity in neural circuits of pain have provided mechanistic insights and linked various …
Neuropathic pain: mechanism-based therapeutics
K Bannister, J Sachau, R Baron… - Annual Review of …, 2020 - annualreviews.org
Neuropathic pain (NeP) can result from sources as varied as nerve compression,
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …
channelopathies, autoimmune disease, and incision. By identifying the neurobiological …
[HTML][HTML] The transition of acute postoperative pain to chronic pain: an integrative overview of research on mechanisms
CR Chapman, CJ Vierck - The Journal of pain, 2017 - Elsevier
The nature of the transition from acute to chronic pain still eludes explanation, but chronic
pain resulting from surgery provides a natural experiment that invites clinical …
pain resulting from surgery provides a natural experiment that invites clinical …
Early neonatal pain—a review of clinical and experimental implications on painful conditions later in life
MD Williams, BDX Lascelles - Frontiers in pediatrics, 2020 - frontiersin.org
Modern health care has brought our society innumerable benefits but has also introduced
the experience of pain very early in life. For example, it is now routine care for newborns to …
the experience of pain very early in life. For example, it is now routine care for newborns to …
[HTML][HTML] Fibromyalgia pathophysiology
M Gyorfi, A Rupp, A Abd-Elsayed - Biomedicines, 2022 - mdpi.com
This article examines the biological, genetic, and environmental aspects of fibromyalgia that
may have an impact on its pathogenesis. Symptoms of fibromyalgia may be related to …
may have an impact on its pathogenesis. Symptoms of fibromyalgia may be related to …