Spatially distinguished, multiplex nucleic acid analysis of biological specimens

J Frisén, P Ståhl, J Lundeberg, GM Cann… - US Patent …, 2020 - Google Patents
(57) ABSTRACT A method for spatially tagging nucleic acids of a biological specimen,
including steps of (a) providing a solid support comprising different nucleic acid probes that …

Methods and systems for determining spatial patterns of biological targets in a sample

MS Chee, DA Routenberg - US Patent 10,774,372, 2020 - Google Patents
The present disclosure provides methods and assay systems for use in spatially encoded
biological assays, including assays to determine a spatial pattern of abundance, expres …

Nucleic acid sequencing

T Hauling, M Kühnemund - US Patent 11,352,667, 2022 - Google Patents
(57) ABSTRACT A nucleic acid sequencing method involving contacting a spatially defined
target nucleic acid sequence with N labeled oligonucleotide probes and performing …

RNA templated ligation

M Nilsson, M Kühnemund, T Krzywkowski - US Patent 11,597,965, 2023 - Google Patents
the present invention relates to the field of nucleic acid detection. Specifically, the present
invention provides methods for detecting target nucleic acid sequences in a target nucleic …

Spatially distinguished, multiplex nucleic acid analysis of biological specimens

J Frisen, P Stahl, J Lundeberg, GM Cann… - US Patent …, 2022 - Google Patents
A method for spatially tagging nucleic acids of a biological specimen, including steps of (a)
providing a solid support comprising different nucleic acid probes that are randomly located …

Spatially encoded biological assays

MS Chee - US Patent 10,662,467, 2020 - Google Patents
The present invention provides assays and assay systems for use in spatially encoded
biological assays. The invention provides an assay system comprising an assay capable of …

Spatially encoded biological assays

MS Chee - US Patent 10,480,022, 2019 - Google Patents
The present invention provides assays and assay systems for use in spatially encoded
biological assays. The invention provides an assay system comprising an assay capable of …

Methods and systems for sample processing or analysis

E Daugharthy, R Terry - US Patent 11,193,163, 2021 - Google Patents
8,460,865 B2 6/2013 Chee et al. 8,501,459 B2 8/2013 Chen et al. 8,551,710 B2 10/2013
Bernitz et al. 9,201,063 B2 12/2015 Sood et al. 9,217,151 B2 12/2015 Yin et al. 9,914,967 …

Methods and systems for determining spatial patterns of biological targets in a sample

MS Chee, DA Routenberg - US Patent 11,753,674, 2023 - Google Patents
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-
oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo …

Generating capture probes for spatial analysis

Y Yin, EPR Iyer, Z Bent, S Giacomello… - US Patent …, 2023 - Google Patents
2021-06-10 Assigned to 10X GENOMICS, INC. reassignment 10X GENOMICS, INC.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …