Inhibitory potential of nitrogen, oxygen and sulfur containing heterocyclic scaffolds against acetylcholinesterase and butyrylcholinesterase
Heterocycles are the key structures in organic chemistry owing to their immense applications
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
in the biological, chemical, and pharmaceutical fields. Heterocyclic compounds perform …
Novel small molecule therapeutic agents for Alzheimer disease: Focusing on BACE1 and multi-target directed ligands
Alzheimer's Disease (AD) is a progressive neurodegenerative disorder that effects 50 million
people worldwide. In this review, AD pathology and the development of novel therapeutic …
people worldwide. In this review, AD pathology and the development of novel therapeutic …
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease
Alzheimer's disease (AD) is a progressive brain disorder associated with slow loss of brain
functions leading to memory failure and modest changes in behavior. The multifactorial …
functions leading to memory failure and modest changes in behavior. The multifactorial …
[HTML][HTML] Indole-3 carbinol and diindolylmethane mitigated β-amyloid-induced neurotoxicity and acetylcholinesterase enzyme activity: in silico, in vitro, and network …
Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …
beta-amyloid (Aβ) deposition and increased acetylcholinesterase (AchE) enzyme activities …
Design, Synthesis, and Biological Evaluation of Piperazine and N-Benzylpiperidine Hybrids of 5-Phenyl-1,3,4-oxadiazol-2-thiol as Potential Multitargeted Ligands for …
Our present work demonstrates the successful design and synthesis of a new class of
compounds based upon a multitargeted directed ligand design approach to discover new …
compounds based upon a multitargeted directed ligand design approach to discover new …
Pyrazole scaffold synthesis, functionalization, and applications in Alzheimer's disease and Parkinson's disease treatment (2011–2020)
X Li, Y Yu, Z Tu - Molecules, 2021 - mdpi.com
The remarkable prevalence of pyrazole scaffolds in a versatile array of bioactive molecules
ranging from apixaban, an anticoagulant used to treat and prevent blood clots and stroke, to …
ranging from apixaban, an anticoagulant used to treat and prevent blood clots and stroke, to …
Catalytic Asymmetric [4+1] Spiroannulation of α-Bromo-β-Naphthols with Azoalkenes by an Electrophilic Dearomatization/SRN1-Debromination Approach
L Bai, X Luo, Y Ge, H Wang, J Liu, Y Wang… - CCS …, 2022 - chinesechemsoc.org
An enantioselective [4+ 1] spiroannulation of α-bromo-β-naphthols with azoalkenes has
been developed for the one-step construction of a new class of pyrazoline-based spirocyclic …
been developed for the one-step construction of a new class of pyrazoline-based spirocyclic …
Computational Prediction of 3, 5-Diaryl-1H-Pyrazole and spiropyrazolines derivatives as potential acetylcholinesterase inhibitors for alzheimer disease treatment by …
The efficacy of 40 synthesized variants of 3, 5-diaryl-1H-pyrazole and spiropyrazoline'
derivatives as acetylcholinesterase inhibitors is verified using a quantitative three …
derivatives as acetylcholinesterase inhibitors is verified using a quantitative three …
A review on recent development of novel heterocycles as acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
Alzheimer's Disease (AD), affecting a large population worldwide, is characterized by the old
population's loss of memory and learning ability. Cholinergic deficiency is associated with …
population's loss of memory and learning ability. Cholinergic deficiency is associated with …
Structure-based screening and molecular dynamics simulation studies for the identification of potential acetylcholinesterase inhibitors
Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative disease
characterised by the appearance of amyloid β plaques and neurofibrillary tangles in the …
characterised by the appearance of amyloid β plaques and neurofibrillary tangles in the …