Calcium signalling in T cells
Abstract Calcium (Ca2+) signalling is of paramount importance to immunity. Regulated
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …
increases in cytosolic and organellar Ca2+ concentrations in lymphocytes control complex …
Kawasaki disease: pathophysiology and insights from mouse models
Kawasaki disease is an acute febrile illness and systemic vasculitis of unknown aetiology
that predominantly afflicts young children, causes coronary artery aneurysms and can result …
that predominantly afflicts young children, causes coronary artery aneurysms and can result …
Kawasaki disease: pathophysiology and insights from mouse models
Kawasaki disease is an acute febrile illness and systemic vasculitis of unknown aetiology
that predominantly afflicts young children, causes coronary artery aneurysms and can result …
that predominantly afflicts young children, causes coronary artery aneurysms and can result …
Regulation of T helper cell fate by TCR signal strength
T cells are critical in orchestrating protective immune responses to cancer and an array of
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …
pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting …
Intracellular calcium release channels: an update
Ryanodine receptors (RyRs) and inositol 1, 4, 5‐trisphosphate receptors (IP3Rs) are
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …
calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we …
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI
Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …
Calcium signaling mechanisms in T lymphocytes
Elevation of intracellular free Ca2+ is one of the key triggering signals for T-cell activation by
antigen. A remarkable variety of Ca2+ signals in T cells, ranging from infrequent spikes to …
antigen. A remarkable variety of Ca2+ signals in T cells, ranging from infrequent spikes to …
Calcium signaling in immune cells
Calcium acts as a second messenger in many cell types, including lymphocytes. Resting
lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen …
lymphocytes maintain a low concentration of Ca2+. However, engagement of antigen …
Store depletion and calcium influx
Calcium influx in nonexcitable cells regulates such diverse processes as exocytosis,
contraction, enzyme control, gene regulation, cell proliferation, and apoptosis. The dominant …
contraction, enzyme control, gene regulation, cell proliferation, and apoptosis. The dominant …
Essential roles of intracellular calcium release channels in muscle, brain, metabolism, and aging
Calcium (Ca2+) release from intracellular stores controls numerous cellular processes,
including cardiac and skeletal muscle contraction, synaptic transmission and metabolism …
including cardiac and skeletal muscle contraction, synaptic transmission and metabolism …