This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …

Medulloblastoma is the most common malignant paediatric brain tumour, with~ 30%
mediated by Sonic hedgehog signalling. Vismodegib-mediated inhibition of the Sonic …

The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is
essential for proper neural function. An unusually low rate of vesicular transport …

Extracellular vesicles (EVs) are small vesicles released by donor cells that can be taken up
by recipient cells. Despite their discovery decades ago, it has only recently become …

Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries
characterized by a local accumulation of cholesterol and non-resolving inflammation …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Proper brain function depends on neurovascular coupling: neural activity rapidly increases
local blood flow to meet moment-to-moment changes in regional brain energy demand …

Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier …

Pulmonary hypertension is a common hemodynamic complication of heart failure. Interest in
left-sided pulmonary hypertension has increased remarkably in recent years because its …