The changing metabolic landscape of bile acids–keys to metabolism and immune regulation

I Mohanty, C Allaband, H Mannochio-Russo… - Nature reviews …, 2024 - nature.com
Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …

Bacillus cereus food intoxication and toxicoinfection

J Jovanovic, VFM Ornelis, A Madder… - … Reviews in Food …, 2021 - Wiley Online Library
Bacillus cereus is one of the leading etiological agents of toxin‐induced foodborne
diseases. Its omnipresence in different environments, spore formation, and its ability to adapt …

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: relationship to neuroimaging and CSF biomarkers

K Nho, A Kueider-Paisley… - Alzheimer's & …, 2019 - Elsevier
Abstract Introduction Bile acids (BAs) are the end products of cholesterol metabolism
produced by human and gut microbiome co-metabolism. Recent evidence suggests gut …

Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy

Y Zheng, S Wang, J Wu, Y Wang - Journal of Translational Medicine, 2023 - Springer
Metabolic dysfunction-associated fatty liver disease (MAFLD) is among the most widespread
metabolic disease globally, and its associated complications including insulin resistance …

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

NL Price, AP Gomes, AJY Ling, FV Duarte… - Cell metabolism, 2012 - cell.com
Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …

[HTML][HTML] Nonalcoholic fatty liver disease (NAFLD). Mitochondria as players and targets of therapies?

A Di Ciaula, S Passarella, H Shanmugam… - International Journal of …, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and
represents the hepatic expression of several metabolic abnormalities of high epidemiologic …

Bile-acid-induced cell injury and protection

MJ Perez, O Briz - World journal of gastroenterology: WJG, 2009 - pmc.ncbi.nlm.nih.gov
Several studies have characterized the cellular and molecular mechanisms of hepatocyte
injury caused by the retention of hydrophobic bile acids (BAs) in cholestatic diseases. BAs …

Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies

A Samsel, S Seneff - Surgical neurology international, 2015 - pmc.ncbi.nlm.nih.gov
Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for
multiple essential functions in the body. A recent study on cows fed genetically modified …

SRT1720 improves survival and healthspan of obese mice

RK Minor, JA Baur, AP Gomes, TM Ward, A Csiszar… - Scientific reports, 2011 - nature.com
Sirt1 is an NAD+-dependent deacetylase that extends lifespan in lower organisms and
improves metabolism and delays the onset of age-related diseases in mammals. Here we …

[PDF][PDF] Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

MD Aleo, Y Luo, R Swiss, PD Bonin, DM Potter… - …, 2014 - Wiley Online Library
Drug‐induced liver injury (DILI) accounts for 20‐40% of all instances of clinical hepatic
failure and is a common reason for withdrawal of an approved drug or discontinuation of a …