The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation
and trafficking of inflammatory mediators as well as tumor progression and metastasis. The …

Precision medicine relies on validated biomarkers with which to better classify patients by
their probable disease risk, prognosis and/or response to treatment. Although …

More than 1000 candidate-gene association studies on genetic susceptibility to lung cancer
have been published over the last two decades but with few consensuses for the likely …

MicroRNAs (miRNAs) comprise a class of short, non-coding RNAs that directly target 3′
UTR of mRNA, causing subsequent degradation or suppression of translation. Here, we …

Chemokines and their receptors play important roles in the pathophysiology of many
diseases by regulating the cellular migration of major inflammatory and immune players …

Single nucleotide polymorphisms (SNPs) have been classically used for dissecting various
human complex disorders using candidate gene studies. During the last decade, large scale …

Genome-wide association studies (GWAS) have identified numerous genetic variants that
are associated with lung cancer risk, but the biological mechanisms underlying these …

Abstract The M iRNA S NP D isease D atabase (MSDD, http://www. bio-bigdata. com/msdd/)
is a manually curated database that provides comprehensive experimentally supported …

Lung cancer is a highly intricate and heterogeneous disease with genomic diversity in each
subtype. Global analyses of gene expression and sequencing provided us new …

Chemokines and their receptors form a complex network controlling leukocyte migration,
particularly during infection and inflammation. Besides their critical contributions to the …