[HTML][HTML] Pathogenesis of endometriosis and endometriosis-associated cancers

A Adilbayeva, J Kunz - International journal of molecular sciences, 2024 - mdpi.com
Endometriosis is a hormone-dependent, chronic inflammatory condition that affects 5–10%
of reproductive-aged women. It is a complex disorder characterized by the growth of …

Endometriosis: recent advances that could accelerate diagnosis and improve care

MJ Griffiths, AW Horne, DA Gibson, N Roberts… - Trends in Molecular …, 2024 - cell.com
Endometriosis is a common disorder associated with pain, gastrointestinal and urinary
symptoms, infertility, and fatigue. It is defined by the presence of endometrial-like lesions …

An integrated single-cell reference atlas of the human endometrium

M Marečková, L Garcia-Alonso, M Moullet, V Lorenzi… - Nature Genetics, 2024 - nature.com
The complex and dynamic cellular composition of the human endometrium remains poorly
understood. Previous endometrial single-cell atlases profiled few donors and lacked …

Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk

IM McGrath… - Human Genetics, 2023 - Springer
Comorbid conditions can be driven by underlying pleiotropic and causal mechanisms that
can provide insights into shared molecular and biological processes contributing to disease …

Pollution and endometriosis: a deep dive into the environmental impacts on women's health

A Vallée, PF Ceccaldi, M Carbonnel… - … Journal of Obstetrics …, 2024 - Wiley Online Library
Background The interaction between pollution and endometriosis is a pressing issue that
demands immediate attention. The impact of pollution, particularly air and water pollution, or …

Association of endometriosis with cardiovascular disease: Genetic aspects

VM Vazgiourakis, MI Zervou… - International …, 2023 - spandidos-publications.com
Cardiovascular disease (CVD) comprises a broad spectrum of pathological conditions that
affect the heart or blood vessels, including sequelae that arise from damaged vasculature in …

Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone

IM McGrath… - BMC medicine, 2023 - Springer
Background Endometriosis affects 1 in 9 women, yet it is poorly understood with long
diagnostic delays, invasive diagnoses, and poor treatment outcomes. Characterised by the …

Nociceptor-to-macrophage communication through CGRP/RAMP1 signaling drives endometriosis-associated pain and lesion growth in mice

V Fattori, TH Zaninelli, FS Rasquel-Oliveira… - Science translational …, 2024 - science.org
Endometriosis is a debilitating and painful gynecological inflammatory disease affecting up
to 15% of women and transgender men. Current treatments are ineffective for a substantial …

Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring

S Benonisdottir, VJ Straub, A Kong, MC Mills - Nature Aging, 2024 - nature.com
Substantial shifts in reproductive behaviors have recently taken place in many high-income
countries including earlier age at menarche, advanced age at childbearing, rising …

Deep infiltrating endometriosis in adolescence: early diagnosis and possible Prevention of Disease Progression

FG Martire, M Giorgi, C D'Abate, I Colombi… - Journal of Clinical …, 2024 - mdpi.com
Endometriosis has a prevalence of 10% worldwide in premenopausal women. Probably,
endometriosis begins early in the life of young girls, and it is commonly diagnosed later in …