The role of JNk signaling pathway in obesity-driven insulin resistance

J Feng, S Lu, B Ou, Q Liu, J Dai, C Ji… - … syndrome and obesity, 2020 - Taylor & Francis
Obesity is not only closely related to insulin resistance but is one of the main factors leading
to the formation of Type 2 Diabetes (T2D) too. The c-Jun N-terminal kinase (JNK) family is a …

Adipocytes in breast cancer, the thick and the thin

I Rybinska, R Agresti, A Trapani, E Tagliabue, T Triulzi - Cells, 2020 - mdpi.com
It is well established that breast cancer development and progression depend not only on
tumor-cell intrinsic factors but also on its microenvironment and on the host characteristics …

Potential role of insulin growth-factor-binding protein 2 as therapeutic target for obesity-related insulin resistance

H Boughanem, EM Yubero-Serrano… - International journal of …, 2021 - mdpi.com
Evidence from observational and in vitro studies suggests that insulin growth-factor-binding
protein type 2 (IGFBP2) is a promising protein in non-communicable diseases, such as …

Association between serum vitamin B12 and global DNA methylation in colorectal cancer patients

H Boughanem, P Hernandez-Alonso, A Tinahones… - Nutrients, 2020 - mdpi.com
Vitamin B12 has been widely related to methionine metabolism, which is an essential
component for biological methylation reactions, including DNA methylation. However, the …

[HTML][HTML] PPAR-γ gene expression in human adipose tissue is associated with weight loss after sleeve gastrectomy

JL Torres, R Usategui-Martin… - Journal of …, 2022 - Elsevier
Background The peroxisome proliferator-activated receptor (PPAR)-γ plays a key role in
adipose tissue differentiation and fat metabolism. However, it is unclear which factors may …

JNK signaling pathway in metabolic disorders: An emerging therapeutic target

R Garg, S Kumariya, R Katekar, S Verma… - European Journal of …, 2021 - Elsevier
Metabolic Syndrome is a multifactorial disease associated with increased risk of
cardiovascular disorders, type 2 diabetes mellitus, fatty liver disease, etc. Various stress …

Role of FoxO1 in regulating autophagy in type 2 diabetes mellitus

X Li, T Wan, Y Li - Experimental and Therapeutic …, 2021 - spandidos-publications.com
Type 2 diabetes mellitus (T2DM) is a major chronic disease that is characterized by
pancreatic β-cell dysfunction and insulin resistance. Autophagy is a highly conserved …

Chitosan oligosaccharide ameliorated obesity by reducing endoplasmic reticulum stress in diet-induced obese rats

X Deng, Z Ye, H Cao, Y Bai, Q Che, J Guo, Z Su - Food & function, 2020 - pubs.rsc.org
Objective: This study aimed to determine whether chitosan oligosaccharide (COST)
improves overweight by reducing endoplasmic reticulum (ER) stress in the liver and liver …

A rich-nutritious cultured meat via bovine myocytes and adipocytes co-culture: Novel Prospect for cultured meat production techniques

Y Wang, D Zhuang, N Munawar, L Zan, J Zhu - Food Chemistry, 2024 - Elsevier
Cultured meat, an emerging meat production technology, has reduced environmental
burden as well as provide healthier and more sustainable method of meat culture. Fat in …

Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity

S Yu, HM Lee, J Lee, JT Hwang, HK Choi… - International Journal of …, 2024 - mdpi.com
Excessive lipid accumulation in adipocytes is a primary contributor to the development of
metabolic disorders, including obesity. The consumption of bioactive compounds derived …