Targeting cannabinoid receptors: current status and prospects of natural products
Cannabinoid receptors (CB1 and CB2), as part of the endocannabinoid system, play a
critical role in numerous human physiological and pathological conditions. Thus …
critical role in numerous human physiological and pathological conditions. Thus …
Multiple functions of endocannabinoid signaling in the brain
I Katona, TF Freund - Annual review of neuroscience, 2012 - annualreviews.org
Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …
Mitochondrial CB1 receptors regulate neuronal energy metabolism
G Bénard, F Massa, N Puente, J Lourenço… - Nature …, 2012 - nature.com
The mammalian brain is one of the organs with the highest energy demands, and
mitochondria are key determinants of its functions. Here we show that the type-1 …
mitochondria are key determinants of its functions. Here we show that the type-1 …
[BOOK][B] Endocannabinoids and their pharmacological actions
RG Pertwee - 2015 - Springer
The endocannabinoid system consists of G protein-coupled cannabinoid CB 1 and CB 2
receptors, of endogenous compounds known as endocannabinoids that can target these …
receptors, of endogenous compounds known as endocannabinoids that can target these …
Early phytocannabinoid chemistry to endocannabinoids and beyond
Isolation and structure elucidation of most of the major cannabinoid constituents—including
Δ9-tetrahydrocannabinol (Δ9-THC), which is the principal psychoactive molecule in …
Δ9-tetrahydrocannabinol (Δ9-THC), which is the principal psychoactive molecule in …
[HTML][HTML] 2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain
Arachidonoylglycerol (2-AG) is a signaling lipid in the central nervous system that is a key
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …
regulator of neurotransmitter release. 2-AG is an endocannabinoid that activates the …
Why do cannabinoid receptors have more than one endogenous ligand?
The endocannabinoid system was revealed following the understanding of the mechanism
of action of marijuana's major psychotropic principle, Δ 9-tetrahydrocannabinol, and …
of action of marijuana's major psychotropic principle, Δ 9-tetrahydrocannabinol, and …
Parsing the players: 2‐arachidonoylglycerol synthesis and degradation in the CNS
N Murataeva, A Straiker… - British journal of …, 2014 - Wiley Online Library
The endogenous cannabinoid signalling system, composed of endogenous cannabinoids,
cannabinoid receptors and the enzymes that synthesize and degrade the endogenous …
cannabinoid receptors and the enzymes that synthesize and degrade the endogenous …
The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
V Di Marzo - Pharmacological research, 2009 - Elsevier
The endocannabinoid signalling system includes:(1) at least two G-protein-coupled
receptors, known as the cannabinoid CB1 and CB2 receptors and discovered following …
receptors, known as the cannabinoid CB1 and CB2 receptors and discovered following …
The endocannabinoid system: pivotal orchestrator of obesity and metabolic disease
W Mazier, N Saucisse, B Gatta-Cherifi… - Trends in Endocrinology & …, 2015 - cell.com
The endocannabinoid system (ECS) functions to adjust behavior and metabolism according
to environmental changes in food availability. Its actions range from the regulation of …
to environmental changes in food availability. Its actions range from the regulation of …