Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique
biophysical properties: a small headgroup; negative charge; and a phosphomonoester …

Phosphatidic acid (PA), the simplest phospholipid, acts as a key metabolic intermediate and
second messenger that impacts diverse cellular and physiological processes across species …

Lipids function not only as the major structural components of cell membranes, but also as
molecular messengers that transduce signals to trigger downstream signaling events in the …

Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to generate phosphatidic
acid (PA). Mammalian DGK consists of ten isozymes (α–κ) and governs a wide range of …

In yeast and higher eukaryotes, phospholipids and triacylglycerol are derived from
phosphatidate at the nuclear/endoplasmic reticulum membrane. In de novo biosynthetic …

Infection of human cells by the severe acute respiratory syndrome coronavirus 2 (SARS-
CoV2) relies on its binding to a specific receptor and subsequent fusion of the viral and host …

Activities of ATP binding cassette (ABC) proteins are regulated by multiple mechanisms,
including protein interactions, phosphorylation, proteolytic processing, and/or …

Sphingolipids are essential in membrane trafficking and cellular homeostasis. Here, we
show that sphingolipids containing very long-chain fatty acids (VLCFAs) promote homotypic …

The ability to determine the binding affinity of lipids to proteins is an essential part of
understanding protein-lipid interactions in membrane trafficking, signal transduction and …

ApoB lipoproteins (apo B-Lp) are produced in hepatocytes, and their secretion requires the
cargo receptor sortilin. We examined the secretion of apo B-Lp-containing very low-density …