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Regulation of intestinal lipid metabolism: current concepts and relevance to disease
Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …
Triglyceride metabolism in the liver
Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …
Commensal Cutibacterium acnes induce epidermal lipid synthesis important for skin barrier function
Lipid synthesis is necessary for formation of epithelial barriers and homeostasis with
external microbes. An analysis of the response of human keratinocytes to several different …
external microbes. An analysis of the response of human keratinocytes to several different …
Spatial transcriptomics stratifies psoriatic disease severity by emergent cellular ecosystems
Whereas the cellular and molecular features of human inflammatory skin diseases are well
characterized, their tissue context and systemic impact remain poorly understood. We thus …
characterized, their tissue context and systemic impact remain poorly understood. We thus …
[HTML][HTML] Small intestine microbiota regulate host digestive and absorptive adaptive responses to dietary lipids
K Martinez-Guryn, N Hubert, K Frazier, S Urlass… - Cell host & …, 2018 - cell.com
The gut microbiota play important roles in lipid metabolism and absorption. However, the
contribution of the small bowel microbiota of mammals to these diet-microbe interactions …
contribution of the small bowel microbiota of mammals to these diet-microbe interactions …
[HTML][HTML] New targets for NAFLD
Non-alcoholic fatty liver disease (NAFLD) is a growing cause of chronic liver disease
worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and …
worldwide. It is characterised by steatosis, liver inflammation, hepatocellular injury and …
Lipid droplet biogenesis
Lipid droplets (LDs) are ubiquitous organelles that store neutral lipids for energy or
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …
membrane synthesis and act as hubs for metabolic processes. Cells generate LDs de novo …
Cytosolic lipolysis and lipophagy: two sides of the same coin
Fatty acids are the most efficient substrates for energy production in vertebrates and are
essential components of the lipids that form biological membranes. Synthesis of …
essential components of the lipids that form biological membranes. Synthesis of …
[HTML][HTML] Acyl-CoA: diacylglycerol acyltransferase: Properties, physiological roles, metabolic engineering and intentional control
Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …
Bioactive lipid species and metabolic pathways in progression and resolution of nonalcoholic steatohepatitis
The prevalence of nonalcoholic steatohepatitis (NASH) is increasing worldwide, yet there
are no effective treatments. A decade has passed since the initial lipidomics analyses of liver …
are no effective treatments. A decade has passed since the initial lipidomics analyses of liver …