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Use of human iPSC-CMs in nonclinical regulatory studies for cardiac safety assessment
Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) provide a
human-relevant platform for cardiac function assessment. Alternative assays using hiPSC …
human-relevant platform for cardiac function assessment. Alternative assays using hiPSC …
Current status of cardiac regenerative therapy using induced pluripotent stem cells
Heart failure (HF) is a life-threatening disorder and is treated by drug therapies and surgical
interventions such as heart transplantation and left ventricular assist device (LVAD) …
interventions such as heart transplantation and left ventricular assist device (LVAD) …
Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
Many oncology drugs have been found to induce cardiotoxicity in a subset of patients, which
significantly limits their clinical use and impedes the benefit of lifesaving anticancer …
significantly limits their clinical use and impedes the benefit of lifesaving anticancer …
[HTML][HTML] Multifactorial approaches to enhance maturation of human iPSC-derived cardiomyocytes
Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …