Synthesis of chalcones derivatives and their biological activities: a review

NAA Elkanzi, H Hrichi, RA Alolayan, W Derafa… - ACS …, 2022 - ACS Publications
Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

[HTML][HTML] Bis-chalcones: A review of synthetic methodologies and anti-inflammatory effects

R Pereira, AMS Silva, D Ribeiro, VLM Silva… - European Journal of …, 2023 - Elsevier
Chalcones are bioactive molecules of natural and synthetic sources, whose
physicochemical properties, reactivity, and biological activities are well-known among the …

Synthesis and biological activities of novel chalcone derivatives containing pyrazole oxime ethers

D Hu, N Zhang, Q Zhou, Y Zhou, C Gong, Y Zhang… - Fitoterapia, 2023 - Elsevier
A series of novel chalcone derivatives containing pyrazole oxime ethers were designed and
synthesized. The structures of all the target compounds were determined by NMR and …

Non-small cell lung cancer sensitisation to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors

H Gamal, KA Ismail, AMME Omar, M Teleb… - Journal of Enzyme …, 2024 - Taylor & Francis
Cisplatin remains the unchallenged standard therapy for NSCLC. However, it is not
completely curative due to drug resistance and oxidative stress-induced toxicity. Drug …

Synthesis and In vitro evaluation of bichalcones as novel anti-toxoplasma agents

F Mazzone, MKT Klischan, J Greb, SHJ Smits… - Frontiers in …, 2024 - frontiersin.org
Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, an apicomplexan
parasite that infects approximately a third of the world's human population. This disease can …

[HTML][HTML] Design, synthesis and biological activity of novel chalcone derivatives containing indole

D Hu, N Zhang, Y Zhang, C Yuan, C Gong… - Arabian Journal of …, 2023 - Elsevier
In this study, 24 chalcone derivatives containing indole were designed and synthesized.
Some of the target compounds exhibited significant antiviral and antibacterial effects. The …

Photoinduced, Metal-Free Hydroacylation of Aromatic Alkynes for Synthesis of α,β-Unsaturated Ketones via C(sp3)–H Functionalization

AK Kushwaha, A Kamal, HK Singh, SK Maury… - Organic …, 2024 - ACS Publications
Despite the notable advancements made over the past decade in achieving carbon–carbon
bonds by transition-metal-catalyzed cross-coupling processes, metal-free cross-coupling …

Synthesis of some chalcones derivatives series and their antituberculosis activity

N Noviany, H Osman, S Mohamad, S Hadi… - Pure and Applied …, 2024 - degruyter.com
Chalcone is an important biosynthetic precursor, due to the diverse pharmacological
activities. The aim of this current study was to synthesize 14 new chalcone derivatives …

Versatile carrier-free binary nanodrug based on metformin/epigallocatechin gallate nanoparticles: exploring its properties and potential in cancer treatment

H Zou, EK Bian, J He, W Wu, C Deng - Biomaterials Science, 2025 - pubs.rsc.org
Epigallocatechin gallate (EGCG), an important active component extracted from green tea,
has attracted much attention due to its multiple biological activities such as antioxidant …

Probing the Fascinating Role of Eu-AgNPs in the Synthesis of Bioactive Substituted Chalcones as a Green Matrix and Study of Their Biological Potential

P Singh, P Yadav, S Bala, J Kaur - Journal of Organometallic Chemistry, 2025 - Elsevier
The demand of environment benign and biologically active nanomaterials has spurred the
development of green synthesis methodologies. The aim of present study was to develop a …