T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

The human genetic epidemiology of COVID-19

MEK Niemi, MJ Daly, A Ganna - Nature Reviews Genetics, 2022 - nature.com
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

C Schultheiß, E Willscher, L Paschold, C Gottschick… - Cell Reports …, 2022 - cell.com
Post-acute sequelae of COVID-19 (PASC) is emerging as global problem with unknown
molecular drivers. Using a digital epidemiology approach, we recruited 8,077 individuals to …

Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID

MC Woodruff, KS Bonham, FA Anam, TA Walker… - Nature …, 2023 - nature.com
While immunologic correlates of COVID-19 have been widely reported, their associations
with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of …

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

T Le Voyer, AV Parent, X Liu, A Cederholm, A Gervais… - Nature, 2023 - nature.com
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …

COVID-19 2022 update: transition of the pandemic to the endemic phase

M Biancolella, VL Colona, R Mehrian-Shai, JL Watt… - Human genomics, 2022 - Springer
COVID-19, which is caused by the SARS-CoV-2, has ravaged the world for the past 2 years.
Here, we review the current state of research into the disease with focus on its history …

[HTML][HTML] A review on chikungunya virus epidemiology, pathogenesis and current vaccine development

TYV de Lima Cavalcanti, MR Pereira, SO de Paula… - Viruses, 2022 - mdpi.com
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that recently re-emerged in
many parts of the world causing large-scale outbreaks. CHIKV infection presents as a febrile …

Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

S Mohandas, P Jagannathan, TJ Henrich, ZA Sherif… - Elife, 2023 - elifesciences.org
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia

Q Zhang, D Matuozzo, J Le Pen, D Lee… - Journal of Experimental …, 2022 - rupress.org
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

J Manry, P Bastard, A Gervais, T Le Voyer… - Proceedings of the …, 2022 - pnas.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR)
doubles with every 5 y of age from childhood onward. Circulating autoantibodies …