Heteromeric nicotinic ACh receptors (nAChRs) were thought to have two orthodox agonist‐
binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by …

Over the last decade, robust human genetic findings have been instrumental in elucidating
the heritable basis of nicotine addiction (NA). They highlight coding and synonymous …

Abstract Changes in high-affinity nicotinic acetylcholine receptors are intricately connected
to neuropathology in Alzheimer's Disease (AD). Protective and cognitive-enhancing roles for …

Attention depends on cholinergic excitation of prefrontal neurons but is sensitive to
perturbation of α5-containing nicotinic receptors encoded by Chrna5. However, Chrna5 …

Phthalates are a group of neurotoxicants with cognitive-disrupting potentials. Given the
structural diversity of phthalates, the corresponding neurotoxicity is dramatically altered. To …

Optimal attention performance requires cholinergic modulation of corticothalamic neurons in
the prefrontal cortex. These pyramidal cells express specialized nicotinic acetylcholine …

Considerable progress has been made in elucidating the relationships between early life
psychobiological and environmental risk factors and the development of tobacco addiction …

Neuropsychiatric disorders are frequently complicated by aggressive behaviors. For some
individuals, existing behavioral and psychopharmacological treatments are ineffective or …

Maternal tobacco smoking during pregnancy constitutes developmental nicotine exposure
(DNE) and is associated with nicotine dependence and neurodevelopmental disorders in …

Integrating expression quantitative trait loci (eQTL) data with genome-wide association
studies (GWAS) enables the discovery of pleiotropic gene regulatory variants that influence …